ISSN: 2572-4118
Breast Cancer: Current Research
黑料网
Our Group organises 3000+ Global Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ 黑料网 Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
黑料网 Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Citations : 114
Indexed In
- RefSeek
- Hamdard University
- EBSCO A-Z
- Publons
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
Vitamin D and biphosphonate in neoadjuvant advanced breast cancer
4th World Congress on Breast Cancer
Selma Sakhri
Medical oncology, Algeria
Posters & Accepted Abstracts: Breast Can Curr Res
DOI:
Abstract
Purpose: Vitamin D and calcium deficiency is associated with increased breast cancer risk and decreased breast cancer survival. The purpose of this study is to determine whether the addition of vitamin D and Zoledronic Acid (ZA) to Neoadjuvant Chemotherapy (NACT) gives complete histological responses. We report a prospective evaluation comparing complete pathological response between different biomolecular sub-groups. Patients & Methods: The study included 431 women with stages III locally advanced breast cancer who received neoadjuvant chemotherapy and Zoledronic acid. All patients were prescribed vitamin D3 (cholecalciferol) 400 IU and calcium carbonate 1,000 mg daily. The main objective is the complete histologic response. Secondary endpoints were the overall survival of patients targeted by the study. Results: Histologic complete response with Zoledronic acid and vit D was 40.13% .the higher in the subgroup Her2/luminal (RH�?卤Her2+) and under Her2+ (HR-Her2+) and the lowest rate was observed in the triple negative group as classified by Sataloff, overall survival was 45.77 months for subgroups (Her2/luminal and in Her2+ group) vs. 44.11 months for triple negative group. Conclusion: Our study confirms the potential protective effects in vitamin D in neoadjuvant breast cancer.Biography
Email: sakhri_selma@yahoo.fr
