Journal of Gastrointestinal & Digestive System
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Epidemiological and clinical evaluation of hepatitis b, hepatitis c, and delta viruses in Tajikistan
Joint Event on 12th Global Gastroenterologists Meeting & 3rd International Conference on Metabolic and Bariatric Surgery
Khakimova Zebinniso
Institute of Gastroenterology - Academy of Medical Sciences of the Ministry of Health and Social Protection, Tajikistan
Posters & Accepted Abstracts: J Gastrointest Dig Syst
DOI:
Abstract
The implication of genotypes is recognized increasingly in the clinical course of hepatitis B virus (HBV) and in response to anti-viral drugs of hepatitis C virus (HCV). Genotypic prevalence of both etiological agents variesgeographicallyand no data are available for Tajikistan. To investigate the epidemiology and clinical significance of HBV and HCVgenotypes in chronic hepatitis (group 1) and liver cirrhosis/hepatocellular carcinoma (HCC) (group2) patients in Tajikistan, 124 patients with chronic liver disease (group 1=84 and group 2=40) were enrolled. Genotypes of HBV, HCV, and delta hepatitis virus (HDV) were deter�?卢mined by sequencing. The overall prevalence of anti-HCV, HCV coreantigen (HCVcAg)and HBsAg was 46% (57/124) and 41.1% (51/124), respec�?卢tively. Coinfection of HCV/HBV, HBV/HDV, and HCV/HBV/HDV was found in 4.8% (6/124), 11.2% (12/124), and 0.8% (1/124) of cases, respectively. HDV genotype 1 was found in 19.6% (10/51) of HBsAgpositive patients. The HBV/HDV coinfec- tion was relatively high in group 2 compared to group 1 (15%vs.7.1%). HCV/1b detected in 84.6% (44/52) of HCVRNA-positive patients,followed by 3a (7.6%), 2a (5.7%), and 2c (1.9%). HBV/D was detected in 94.1% (48/51) of HBsAg-positive patients, followed by HBV/A [5.8% (3/51)]. T1762/A1764 double mutation was associated with livercirrhosis/HCC in HBV-infected patients (P=0.0004). This is the first study on the molecular epidemiology of hepatitis viruses among chronic liver diseases patients in Tajikistan. Among HBV-infected patients, the T1762/A1764 mutation was associated with liver cirrhosis/HCC.Biography
Khakimova Zebinniso is affiliated to the Department of Virology, Institute of Gastroenterology of the Republic of Tajikistan. She has published more than 5 papers in reputed journals.
Email:dustovsamad@gmail.com
