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Abstract

Objectives: To determine whether irritable bowel syndrome is associated with Helicobacter pylori infection and infantile colic. Methods: A retrospective case controlled study was conducted in a local tertiary hospital, Muhayel Aseer (Abha, Saudi Arabia), Abo Hareez Hospital (Sharkia, Egypt) and Hussein University Hospital (Cairo, Egypt). Four hundred and fifty cases of irritable bowel syndrome (IBS) that met the Rome III criteria and one hundred controls (IBS-negative), aged 7-17 years old, were involved in this study. Complete stool analysis including Helicobacter pylori stool antigen test and occult blood in addition to urea breath test, if necessary, were carried out for all pediatric participants. Results: Of the total 450 IBS cases, 212 (47.1%) had reported infantile colic at age 0 - 4 months compared to 7 (7.0%) in control group and family history of IBS was evident in case group (n= 315; 70.0%) versus control group (n=10; 10.0%). Furthermore, H. pylori was present in 192 (42.7%) of IBS cases compared to only 8 (8.0%) in control group. Conclusion: Our findings provide new correlations between childhood IBS and infantile colic as well as H. pylori infection. Moreover, a significant association was found between infantile IBS and family history of IBS.

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