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Abstract

Introduction: Celiac disease is a genetic disorder, it is not uncommon disease the role of diet control is an important factor in the therapy of this disease. Aims & Methods: The aim of this work is to evaluate the effect of diet control on the liver enzymes in an attempt to find the role of liver dysfunction in the symptomatology of this condition. 23 Patients had been diagnosed as a celiac disease since time ranged between 2-36 months included in this study. Diagnosis confirmed by serology (tissue transglutaminaset TGIgG and IgA, and antiendomysial antibody), all the patients were on glutein free diet (GFD). The compliance for the glutein free diet was evaluated as a non-compliant, indeterminant, or compliant based on dietary history, level of Ttg, and endomysial antibody. Results: 11 patients (48%) were compliant based strict diet, normalization of celiac serology, and improvement of symptoms after adhere to the GFD. While 10 patients (43%) were non-compliant with elevated Ttg, and antiendomysial antibody. The remaining two patients (9%) were categorized as indeterminate due to poor diet history, and borderline serology level. Liver enzymes: AST and ALT and US were evaluated for all ALT ranged from 33-76 IU/dl, with mean 48.9 +16.5 IU/L, AST ranged from 52-81 IU/L, with mean of 69.3�±9.3 IU/L. By US among the 12 patient with elevated transaminases, 6 of them (50%) showed evidence of fatty infiltration of the liver, 4 of them (33%) showed normal liver parenchyma, 2 of them (17%) showed gall bladder. Among the 11 patients having normal transaminases, one patient (9%) has evidence of liver cirrhosis. 8 of them (72%) had normal liver parenchyma, and 2 of them (18%) had fatty liver infiltration. Conclusion: Liver enzymes may play a part in the symptoms of the disease and the control of diet may take part in the improvement of liver function

Biography

Ahmed Zaki Helaly received MD from Alexandria University in 1975. He was a visitor Professor in some Universities and currently is an Emeritus Professor of the GIT. He was the Head of the GIT unit for ten years and the Head of the entire Medical Department for 2 years. He was the examiner of the MD degree and MBChB in different University in many countries. He was invited in many congresses as a speaker and as a chairman for different sessions. He spent more than 50 years in the field of GIT diseases.

Email: drhelaly@yahoo.com