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The recent development of a worldwide obesity and type 2 diabetes pandemic has gained wide recognition. In obese subjects,
visceral white adipose tissue is enriched in lymphocytes and macrophages, which have been implicated in contributing to
systemic low-grade inflammation and vascular complications. Bariatric surgery is emerging as a promising tool in the treatment of
morbid obesity and type 2 diabetes by effectively controlling body weight and profoundly improving insulin sensitivity, however,
little is known about the effects of surgery-induced weight loss on visceral adipose inflammatory cell infiltration and vascular
dysfunction. Interferon-gamma (IFN) is the hallmark cytokine of Th1 cells. We hypothesize that bariatric surgery reduces IFN-
induced adipose tissue inflammation and improves vascular function in type 2 diabetic mice. To test this hypothesis, heterozygote
control mice (m Lepr
db
), and homozygote type 2 diabetic mice (Lepr
db
) will be used in the following 7 groups: m Lepr
db
+sham
surgery, m Lepr
db
+ bariatric surgery, Lepr
db
+sham surgery, Lepr
db
+5, 10, 20 and 30 days after bariatric surgery. The results suggest
that 1) bariatric surgery effectively reduced body weight and abdominal adiposity; 2) surgery inhibited IFN-induced adipose
tissue inflammation; 3) surgery improved endothelial function. As the first use of bariatric surgery in type 2 diabetic mice, this
study improved our understanding of the role of IFN-induced adipose inflammation in vascular dysfunction in morbid obesity
and type 2 diabetes and the mechanisms responsible for the therapeutic effects of bariatric surgery on diabetes-related vascular
dysfunction.
Biography
Hanrui Zhang obtained her MD/MSc in Chinese Medicine from Beijing University of Chinese Medicine, and PhD in pharmacology from University of
Missouri. She is author of over 25 papers in the field of obesity, diabetes and cardiovascular diseases in reputable journals such as Arteriosclerosis,
Thrombosis, and Vascular Biology, Basic Research in Cardiology, Journal of Molecular and Cellular Cardiology, American Journal of Physiology-
Heart and Circulatory Physiology, Clinical Science, Obesity, etc. She published over 10 abstracts, co-authored 1 book chapter, and is serving as
editorial board member for 3 journals and reviewer for 10 journals
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