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Abstract

Hepatic steatosis is rapidly becoming the most common metabolic liver disorder in the Western countries. Overfeeding either saturated fat or carbohydrate increases hepatic triglycerides. Our main aim of this study is first time documenting the hepatoprotective potential of nutraceuticals against diet and alcohol induced hepatic steatosis in experimental rat model. Young male Albino Wistar and Sprague Dawley rats fed with fructose enriched diet for 8 weeks to induce NAFLD and non-alcoholic hepatic steatosis (NASH). In addition, one group of fructose enriched diet fed rats was administered together with nutraceuticals (piperine, limonene, naringenin and zingerone). Liver pathology of group 3 showed marked changes which includes micro and macro vesicular steatosis, inflammatory cell infiltration, sinusoidal fibrosis and with a significant increase in the immunohistochemical expression of pro-inflammatory cytokines and fibrotic markers. Body weight, lipid profile and hepatic function indicators were increased and HDL reduced. Administration of nutraceuticals reversed the fructose enriched diet induced changes especially body weight, lipid profile, hepatic function indicators and restored pro-inflammatory cytokines and fibrotic markers as well as pathological alteration of liver. Thus consumption of nutraceuticals in the diet could prevent early hepatic damage in people prone to hepatic steatosis.

Biography

Email: jvictorbiochem@gmail.com