ISSN: 2165-7904
Journal of Obesity & Weight Loss Therapy
黑料网
Our Group organises 3000+ Global Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ 黑料网 Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
黑料网 Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Citations : 2305
Indexed In
- Index Copernicus
- Google Scholar
- Open J Gate
- Genamics JournalSeek
- Centre for Agriculture and Biosciences International (CABI)
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- CABI full text
- Cab direct
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- University of Bristol
- Pubmed
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
In utero exposure to Hypoxis hemerocallidea (African potato) improves glucose tolerance, lipid profiles and antioxidant status in offspring 28 days postpartum
4th International Conference and Exhibition on Obesity and Weight Management
Constance R Sewani-Rusike
Walter Sisulu University, South Africa
Posters-Accepted Abstracts: J Obes Weight Loss Ther
DOI:
Abstract
Intrauterine and early life environments contribute to adult metabolic phenotype. Use of medicinal plants like Hypoxis hemerocallidea during pregnancy is common. This raises the question of whether phytochemicals in medicinal plants may contribute to metabolic intrauterine-programming effects on the offspring that may determine adult metabolic phenotype. Three gestational treatment groups (n=6 rats per group): Control group (distilled water) and two H. hemerocallidea treated groups (150 and 300 mg/kg body weight) were used for the study. Pups were weighed at birth and weekly until 28 days postpartum. OGTT was performed and area under the curve determined. Fasted pups (n=8/group) were terminated and serum collected for lipid profiles and antioxidant status. Liver and kidneys were homogenized for determination of total antioxidant capacity, lipid peroxidation and SOD. Pup weights were similar at birth for all treatment groups but after 21 days, H. hemerocallidea exposed pups had higher body weights (P<0.05) compared to controls. H. hemerocallidea exposed rats had better glucose tolerance and kidney antioxidant status (P<0.05) compared to controls with no effect on liver. H. hemerocallidea exposure resulted in decreased total cholesterol and LDL concentration with no effect on HDL. H. hemerocallidea may have protective programming effects to development of diabetes and oxidative stress in pups exposed in utero. Effects after exposure to obesogenic diet will be investigated.Biography
Email: consewa@hotmail.com
