ºÚÁÏÍø

Abstract

Obesity is a risk factor for developing insulin insensitivity and cardiovascular disease. Adiponectin is a serum protein that is secreted primarily from adipose tissue, with concentrations that are inversely correlated to the body mass index (BMI). Leptin and proinflamatory interleukin-6 (IL-6) are directly proportional with obesity. Natural products Foeniculum vulgare and Anethum graveolens have been reported to have hypoglycemic and insulin-sensitizing activities. In this paper, we explored the effects of combined extract of Foeniculum vulgare and Anethum graveolens on HFD�induced obesity in rats. We randomly divided Sprague- Dawley male rats into four groups: Control, high fat diet (HFD), HFD with the combined extract (0.045 g/kg/day) and HFD with the combined extract (0.45 g/kg/day) groups. Diabetic profile parameters (fasting blood glucose level, serum insulin, HOMA-IR), rat weight, total cholesterol, triglyceride, HDL-C, LDL-C, liver function, kidney function, adiponectin, leptin, IL-6, liver malondialdehyde, glutathione and glutathione peroxidase activity were measured in all groups. Feeding rats HFD for 8 weeks developed features of insulin resistance. These features presented in increased body weight, hyperglycemia, hyperinsulinemia, hypercholesterolemia (with increased LDL-Cholesterol and decreased HDL-Cholesterol) and hypertriglyceridemia and also decreased adiponectin levels and increased leptin and IL-6 levels and decreased glutathione and glutathione peroxidase activity. The combined extract (both doses) treatment decreased fasting glucose significantly, improved levels of diabetic profile parameters, lipid profile, liver and kidney function and elevated adiponectin, decreased leptin and IL-6 and decreased oxidative stress. Our results suggested that the combined extract of Foeniculum vulgare and Anethum graveolens is a unique natural medicine against obesity.

Biography

Email: faynt2001us@yahoo.com